占艳艳 副教授/硕导 学科（方向）：肿瘤学（肿瘤发生发展机制及靶向药物筛选） 所在系部：抗癌研究中心 办公电话：0592-2188223 邮箱：yyzhan@xmu.edu.cn

研究领域：

Exo70是胞外分泌复合体（exocyst）的关键亚基，参与囊泡与质膜的栓系、锚定和融合过程。Exo70在肿瘤发生发展过程中发挥重要的作用，但其作用机制目前尚不清楚。对Exo70在细胞外泌、自噬、侵袭和迁移等过程中的作用及相关分子机制的研究，将有助于探索肿瘤的发生及发展机制，并进一步指导靶向性抗肿瘤药物的筛选和开发。

学习经历：

2000~2004 厦门大学生命科学学院生物科学专业理学学士；

2004~2010 厦门大学生命科学学院细胞生物学专业理学博士。

工作经历：

2011~2013 厦门大学附属第一医院博士后；

2013~至今bat365手机版官网副教授。

代表性成果（#第一作者, *通讯作者）：

1.Ruan H^#, Zhan YY(corresponding)^#,*, Hou J, Xu B, Chen B, Tian Y, Wu D, Zhao Y, Zhang Y, Chen X, Mi P, Zhang L, Zhang S, Wang X, Cao H, Zhang W, Wang H, Li H, Su Y, Zhang XK* and Hu T*. Berberine binds RXRα to suppress β-catenin signaling in colon cancer cells. Oncogene, 2017, 36(50): 6906-6918.

2.Li D, Zhang Y, Liu K, Zhao Y, Xu B, Xu L, Tan L, Tian Y, Li C, Zhang W, Cao H, Zhan YY(corresponding)*, Hu T*. Berberine inhibits colitis-associated tumorigenesis via suppressing inflammatory responses and the consequent EGFR signaling-involved tumor cell growth. Laboratory Investigation, 2017,97(11): 1343-1353.

3.Xiao L^#, Zheng K^#, Lv X, Hou J, Xu L, Zhao Y, Song F, Fan Y, Cao H, Zhang W, Hong X, Zhan YY(corresponding)*, Hu T*. Exo70 is an independent prognostic factor in colon cancer. Scientific Reports, 2017, 7(1): 5039.

4.Xu B^#, Xu M^#, Tian Y, Yu Q, Zhao Y, Chen X, Mi P, Cao H, Zhang B, Song G, Zhan YY(corresponding)*, Hu T*. Matrine induces RIP3-dependent necroptosis in cholangiocarcinoma cells. Cell Death Discovery, 2017, 3: 16096.

5.Zhao Y, Hou J, Mi P, Mao L, Xu L, Zhang Y, Xiao L, Cao H, Zhang W, Zhang B, Song G, Hu T*, Zhan YY(corresponding)*. Exo70 is transcriptionally up-regulated by hepatic nuclear factor 4α and contributes to cell cycle control in hepatoma cells. Oncotarget, 2016, 7(8): 9150-9162.

6.Zhou H^#, Xu M^#, Gao Y, Deng Z, Cao H, Zhang W, Wang Q, Zhang B, Song G*, Zhan Y(corresponding)*, Hu T*. Matrine induces caspase-independent program cell death in hepatocellular carcinoma through bid-mediated nuclear translocation of apoptosis inducing factor. Molecular Cancer, 2014, 13: 59.

7.Zhan YY^#, He JP^#, Chen HZ, Wang WJ, Cai JC*. Orphan receptor TR3 is essential for the maintenance of stem-like properties in gastric cancer cells. Cancer Letters, 2013, 329(1): 37-44.

8.Zhan YY^#, Chen Y^#, Zhang Q^#, Zhuang JJ, Tian M, Chen HZ, Zhang LR, Zhang HK, He JP, Wang WJ, Wu R, Wang Y, Shi C, Yang K, Li AZ, Xin YZ, Li TY, Yang JY, Zheng ZH, Yu CD, Lin SC, Chang C, Huang PQ, Lin T*, Wu Q*. The orphan nuclear receptor Nur77 regulates LKB1 localization and activates AMPK. Nature Chemical Biology, 2012, 8(11): 897-904.

9.Zhan Y^#, Du X^#, Chen H, Liu J, Zhao B, Huang D, Li G, Xu Q, Zhang M, Weimer BC, Chen D, Cheng Z, Zhang L, Li Q, Li S, Zheng Z, Song S, Huang Y, Ye Z, Su W, Lin SC*, Shen Y*, Wu Q*. Cytosporone B is an agonist for nuclear orphan receptor Nur77. Nature Chemical Biology, 2008, 4(9): 548-556.

主持过的重要课题：

1.国家自然科学基金面上项目，2016.12-2019.12

2.国家自然科学基金青年项目，2014.01-2016.12

3.福建省基金杰出青年项目，2017.01-2020.12

4.福建省省属公益类科研院所基本科研专项项目，2017.01-2018.12

5.福建省省属公益类科研院所基本科研专项项目，2015.01-2016.12

6.厦门市重要重大疾病联合攻关项目(联合方)，2016.01-2018.12

7.厦门大学中央高校基本科研业务费，2015.01-2017.12

8.厦门大学中央高校基本科研业务费，2013.05-2013.12

9.中国博士后科学基金面上资助，2012.09-2013.03

已申请的专利：

吴乔、占艳艳、陈航姿、田敏、陈艳、郑忠辉，《以Nur77-LKB1相互作用为靶点的抗糖尿病药物筛选方法》，专利号ZL201110200520.3

所有论文列表（#第一作者, *通讯作者）：

1.Ruan H^#, Zhan YY^#,*, Hou J, Xu B, Chen B, Tian Y, Wu D, Zhao Y, Zhang Y, Chen X, Mi P, Zhang L, Zhang S, Wang X, Cao H, Zhang W, Wang H, Li H, Su Y, Zhang XK* and Hu T*. Berberine binds RXRα to suppress β-catenin signaling in colon cancer cells. Oncogene, 2017, 36(50): 6906-6918. https://www.nature.com/articles/onc2017296.

2.Li D, Zhang Y, Liu K, Zhao Y, Xu B, Xu L, Tan L, Tian Y, Li C, Zhang W, Cao H, Zhan YY*, Hu T*. Berberine inhibits colitis-associated tumorigenesis via suppressing inflammatory responses and the consequent EGFR signaling-involved tumor cell growth. Laboratory Investigation, 2017,97(11): 1343-1353. https://www.nature.com/articles/labinvest201771.

3.Xiao L^#, Zheng K^#, Lv X, Hou J, Xu L, Zhao Y, Song F, Fan Y, Cao H, Zhang W, Hong X, Zhan YY*, Hu T*. Exo70 is an independent prognostic factor in colon cancer. Scientific Reports, 2017, 7(1): 5039. https://www.nature.com/articles/s41598-017-05308-x.

4.Xu B^#, Xu M^#, Tian Y, Yu Q, Zhao Y, Chen X, Mi P, Cao H, Zhang B, Song G, Zhan YY*, Hu T*. Matrine induces RIP3-dependent necroptosis in cholangiocarcinoma cells. Cell Death Discovery, 2017, 3: 16096. https://www.nature.com/articles/cddiscovery201696.

5.Zhao Y, Hou J, Mi P, Mao L, Xu L, Zhang Y, Xiao L, Cao H, Zhang W, Zhang B, Song G, Hu T*, Zhan YY*. Exo70 is transcriptionally up-regulated by hepatic nuclear factor 4α and contributes to cell cycle control in hepatoma cells. Oncotarget, 2016, 7(8): 9150-9162. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4891032.

6.Zhou H^#, Xu M^#, Gao Y, Deng Z, Cao H, Zhang W, Wang Q, Zhang B, Song G*, Zhan Y*, Hu T*. Matrine induces caspase-independent program cell death in hepatocellular carcinoma through bid-mediated nuclear translocation of apoptosis inducing factor. Molecular Cancer, 2014, 13: 59. https://molecular-cancer.biomedcentral.com/articles/10.1186/1476-4598-13-59.

7.Zhan YY^#, He JP^#, Chen HZ, Wang WJ, Cai JC*. Orphan receptor TR3 is essential for the maintenance of stem-like properties in gastric cancer cells. Cancer Letters, 2013, 329(1): 37-44.http://www.cancerletters.info/article/S0304-3835(12)00580-0/fulltext.

8.Zhan YY^#, Chen Y^#, Zhang Q^#, Zhuang JJ, Tian M, Chen HZ, Zhang LR, Zhang HK, He JP, Wang WJ, Wu R, Wang Y, Shi C, Yang K, Li AZ, Xin YZ, Li TY, Yang JY, Zheng ZH, Yu CD, Lin SC, Chang C, Huang PQ, Lin T*, Wu Q*. The orphan nuclear receptor Nur77 regulates LKB1 localization and activates AMPK. Nature Chemical Biology, 2012, 8(11): 897-904. https://www.nature.com/articles/nchembio.1069.

9.Chen HZ^#, Liu QF^#, Li L^#, Wang WJ, Yao LM, Yang M, Liu B, Chen Wei, Zhan YY, Zhang MQ, Cai JC, Zheng ZH, Lin SC, Li BA*, Wu Q*. The orphan receptor TR3 suppresses intestinal tumorigenesis in mice by downregulating Wnt signaling. Gut, 2012, 61(5): 714-724. http://gut.bmj.com/content/61/5/714.long.

10.Liu JJ^#, Zeng HN^#, Zhang LR^#, Zhan YY, Chen Y, Wang Y, Wang J, Xiang SH, Liu WJ, Wang WJ, Chen HZ, Shen YM, Su WJ, Huang PQ, Zhang HK*, and Wu Q*. A Unique Pharmacophore for Activation of the Nuclear Orphan Receptor Nur77 In vivo and In vitro. Cancer Research, 2010, 70(9): 3628-3637. http://cancerres.aacrjournals.org/content/70/9/3628.long.

11.Lei NZ^#, Zhang XY^#, Chen HZ, Wang Yuan, Zhan YY, Zheng ZH, Shen YM, Wu Q*. A feedback regulatory loop between methyltransferase PRMT1 and orphan receptor TR3. Nucleic Acids Research, 2009, 37(3): 832-848. https://academic.oup.com/nar/article/37/3/832/1076689.

12.Zhan Y^#, Du X^#, Chen H, Liu J, Zhao B, Huang D, Li G, Xu Q, Zhang M, Weimer BC, Chen D, Cheng Z, Zhang L, Li Q, Li S, Zheng Z, Song S, Huang Y, Ye Z, Su W, Lin SC*, Shen Y*, Wu Q*. Cytosporone B is an agonist for nuclear orphan receptor Nur77. Nature Chemical Biology, 2008, 4(9): 548-556. https://www.nature.com/articles/nchembio.106.

13.Liu B^#, Wu JF, Zhan YY, Chen HZ, Zhang XY, and Wu Q*. Regulation of the orphan receptor TR3 nuclear functions by JNK phosphorylation. Endocrinology, 2007, 148(1): 34-44. https://academic.oup.com/endo/article/148/1/34/2500819.